Investigación

La investigación que desarrollan los miembros del Servicio de Cardiología se realiza por Grupo de Investigación Cardiovascular dentro del Programa de Enfermedades Cardiovasculares, Respiratorias, Sistémicas y de Envejecimiento celular del IDIBELL (coordinador Dr. Angel Cequier).

Las líneas de investigación y sus coordinadores son las siguientes:

Cardiología Intervencionista: Dr. Angel Cequier

Cirugía Cardíaca: Dr. Albert Miralles

Insuficiencia Cardíaca y Trasplante: Dr. Nicolas Manito

Imagen Cardíaca: Dr. Alex Ruiz-Majoral

Arritmias Cardíacas: Dr. Ignasi Anguera

Laboratorio Investigación Cardiovascular: Dr. Jose Luis Ferreiro

La Unidad de Investigación Clínica está formada por 4 enfermeras- coordinadoras que monitorizan los diferentes estudios propios o Ensayos Clínicos que se realizan en el Servicio.

El Factor de Impacto anual del Grupo de Investigación Cardiovascular en los últimos 5 años ha sido el siguiente:

2011: 279,1

2012: 295,0

2013: 295,3

2014: 381,7

2015: 276,5

Accede al Laboratorio de investigación cardiovascular.

Los artículos más relevantes de los últimos 5 años son los siguientes:

1. Ferreiro JL, Angiolillo DJ. Diabetes and Antiplatelet Therapy in Acute Coronary Syndrome. Circulation, 2011, 123(7):798-813
2. Bueno H, Hernández-Antolín R, Alonso JJ, Betriu A, Cequier A, García EJ, Heras M, López-Sendón JL, Macaya C. Primary angioplasty vs. fibrinolysis in very old patients with acute myocardial infarction: TRIANA (Tratamiento del Infarto Agudo de miocardio eN Ancianos) randomized trial and pooled analysis with previous studies. European Heart Journal, 2011, 32(1):51-60
3. Romaguera R, Wakabayashi K, Laynez-Carnicero A, Sardi G, Maluenda G, Ben-Dor I, Torguson R, Kent KM, Satler LF, Suddath WO, Lindsay J, Pichard AD, Waksman R. Association between severity and long-term mortality in patients experiencing vascular complications after percutaneous coronary intervention. Am J Cardiol, 2011, 109(1):75-81
4. Gomez-Lara J, Brugaletta S, Diletti R, Garg S, Onuma Y, Gogas BD, van Geuns RJ, Dorange C, Veldhof S, Rapoza R, Whitbourn R, Windecker S, Garcia-Garcia HM, Regar E, Serruys PW. A comparative assessment by optical coherence tomography of the performance of the first and second generation of the everolimus-eluting bioresorbable vascular scaffolds. European Heart Journal, 2011, 32(3):294-304
5. Gomez-Lara J, Radu M, Brugaletta S, Farooq V, Diletti R, Onuma Y, Windecker S, Thuesen L, McClean D, Koolen J, Whitbourn R, Dudek D, Smits PC, Regar E, Veldhof S, Rapoza R, Ormiston JA, Garcia-Garcia HM, Serruys PW. Serial analysis of the malapposed and uncovered struts of the new generation of everolimus-eluting bioresorbable scaffold with optical coherence tomography. J Am Coll Cardiol, JACC, 2011, 4(9):789-799
6. Solanich X, Claver E, Carreras F, Giraldo P, Vidaller A, Aguilar R, Cequier A. Myocardial infiltration in Gaucher’s disease detected by cardiac MRI. Int J Cardiol 2012 Feb 23;155(1):e5-6
7. Ferreiro JL, Angiolillo DJ. New Directions in Antiplatelet Therapy. Circ Cardiovasc Interv, 2012 Jun;5(3):433-45
8. Tricoci P, Huang Z, Held C, Leonardi S, Rorick TL, Kilian AM, Jennings LH, Ambrosio G, Bode C, Cequier A, Cornel JH, Diaz R, Erkan A, Huber K, Hudson MP, Jiang L, Jukema JW, Lewis BS, Lincoff AM, Montalescot G, Nicolau JC, Ogawa H, Pfisterer M, Prieto JC, Ruzyllo W, Sinnaeve PR, Storey RF, Valgimigli M, Whellan DJ, Widimsky P, Strony J, Harrington RA, Mahaffey KW. “Thrombin-receptor antagonist vorapaxar in acute coronary syndromes”. New England Journal of Medicine 2012;366(1):20-33
9. Sabate M, Cequier A, Iñiguez A, Serra A, Hernandez-Antolin R, Mainar V, Valgimigli M, Tespili M, den Heijer P, Bethencourt A, Vazquez N, Gómez-Hospital JA, Baz JA, Martin-Yuste V, van Geuns RJ, Alfonso F, Bordes P, Tebaldi M, Masotti M, Silvestro A, Backx B, Brugaletta S, van Es GA, Serruys PW. “Everolimus-eluting stent versus bare-metal stent in ST-segment elevation myocardial infarction (EXAMINATION): 1 year results of a randomised controlled trial”. Lancet. 2012 Oct 27; 380(9852):1482-90.
10. Luis Ferreiro J., Homs S., Berdejo J., Roura G., Gomez-Lara J., Romaguera R., Teruel L., Sanchez-Elvira G., Lucrecia Marcano A., Gomez-Hospital J Antoni, Angiolillo D.J., Cequier A. Clopidogrel pretreatment in primary percutaneous coronary intervention: Prevalence of high ontreatment platelet reactivity and impact on preprocedural patency of the infarct-related artery. Thrombosis and Haemostais.2013 Jul;110(1):110-7
11. Claver E., Cubero N., Cequier A. Diastolic Dysfunction With Nondilated Left Atrium. Chest.2013 Jan;143(1):272-3.
12. Roura G.,Gomez-Lara J.,Ferreiro J.L., Gomez-Hospital J.A., Romaguera R., TeruelL.M., Carreno E.,Esplugas E., Alfonso F., Cequier A. Multislice CT for assessing in-stent dimensions after left main coronary artery stenting: a comparison with three dimensional intravascular ultrasound Heart.2013 Aug;99(15):1106-12.
13. Gomez-Lara J., Brugaletta S., Gomez-Hospital J.A., Luis Ferreiro J., Roura G., Romaguera R., Martin-Yuste V:, Masotti M., Iniguez A., Serra A., Hernandez-Antolin R., Mainar V., Valgimigli M., Tespili M., den Heijer P., Bethencourt A., Vazquez N., Serruys P., Sabate M., Cequier A. Everolimus-eluting stent versus bare metal stent in proximal left anterior descending STelevation myocardial infarction: Insights from the EXAMINATION trial. American Heart Journal. 2013 Jul;166(1):119-26.
14. Ariza A., Luis Ferreiro J., Carlos Sanchez-Salado J., Lorente V., Antoni Gomez-Hospital J., Cequier A. Early Anticoagulation May Improve Preprocedural Patency of the Infarct-related Artery in Primary Percutaneous Coronary Intervention Revista Española de Cardiología.2013 Feb;66(2):148-50.
15. De la Torre Hernandez JM, Baz Alonso JA, Gómez Hospital JA, Alfonso Manterola F, Garcia Camarero T, Gimeno de Carlos F, Roura Ferrer G, Recalde AS, Martínez-Luengas IL, Gomez Lara J, Hernandez Hernandez F, Pérez-Vizcayno MJ, Cequier Fillat A, et al. IVUS-TRONCO-ICP Spanish study. Clinical Impact of Intravascular ltrasound Guidance in Drug-Eluting Stent Implantation for Unprotected Left Main Coronary Disease Pooled Analysis at the Patient-Level of 4 Registries. JACC Cardiovasc Interv. 2014;7(3):244-54
16. Valgimigli M, Sabaté M, Kaiser C, Brugaletta S, de la Torre Hernandez JM, Galatius S, Cequier A, Eberli F, de Belder A, Serruys PW, Ferrante G. Effects of cobalt-chromium everolimus eluting stents or bare metal stent on fatal and non-fatal cardiovascular events: patient level meta-analysis. BMJ. 2014;349:g6427.
17. Ferreiro JL, Bhatt DL, Ueno M, Bauer D, Angiolillo DJ. Impact of Smoking on Long-Term Outcomes in Patients With Atherosclerotic Vascular Disease Treated With Aspirin or Clopidogrel. J Am Coll Cardiol. 2014;63(8):769-77
18. Montalescot G, van ‘t Hof AW, Lapostolle F, Silvain J, Lassen JF, Bolognese L, Cantor WJ, Cequier A, Chettibi M, Goodman SG, Hammett CJ, Huber K, Janzon M, Merkely B, Storey RF, Zeymer U, Stibbe O, Ecollan P, Heutz WM, Swahn E, Collet JP, Willems FF, Baradat C, Licour M, Tsatsaris A, Vicaut E, Hamm CW; ATLANTIC Investigators. Prehospital Ticagrelor in ST-Segment Elevation Myocardial Infarction. N Engl J Med. 2014;371(11):1016-27.
19. Serruys, Patrick W.; Chevalier, Bernard; Dudek, Dariusz; Cequier, Angel; Carrie, Didier; Iniguez, Andres; Dominici, Marcello; van der Schaaf, Rene J.; Haude, Michael; Wasungu, Luc; Veldhof, Susan; Peng, Lei; Staehr, Peter; Grundeken, Maik J.; Ishibashi, Yuki; Garcia-Garcia, Hector M.; Onuma, Yoshinobu. A bioresorbable everolimuseluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes from a randomised controlled trial. Lancet. 2015 Jan 3;385(9962):43-54.
20. Brugaletta, Salvatore; Gori, Tommaso; Low, Adrian F.; Tousek, Petr; Pinar, Eduardo; Gomez-Lara, Josep; Scalone, Giancarla; Schulz, Eberhard; Chan, Mark Y.; Kocka, Viktor; Hurtado, Jose; Gomez-Hospital, Juan Antoni; Muenzel, Thomas; Lee, Chi-Hang; Cequier, Angel; Valdes, Mariano; Widimsky, Petr; Serruys, Patrick W.; Sabate, Manel. Absorb Bioresorbable Vascular Scaffold Versus Everolimus-Eluting Metallic Stent in ST-Segment Elevation Myocardial Infarction: 1-Year Results of a Propensity Score Matching Comparison The BVS-EXAMINATION Study (Bioresorbable Vascular Scaffold-A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-segment Elevation Myocardial Infarction). JACC Cardiovasc Interv. 2015 Jan;8(1 Pt B):189-97.
21. Sabaté M, Brugaletta S, Cequier A, Iñiguez A, Serra A, Jiménez-Quevedo P, Mainar V, Campo G, Tespili M, den Heijer P, Bethencourt A, Vazquez N, van Es GA, Backx B, Valgimigli M, Serruys PW. “Clinical outcomes in patients with ST-segment elevation myocardial infarction treated with everolimus-eluting stents versus bare-metal stents (EXAMINATION): 5-year results of a randomised trial”. Lancet. 2016 Jan 23;387(10016):357-66
22. Anguera, I.; García-Alberola, A.; Dallaglio, P.; Toquero, J.; Pérez, L.; Martínez, J.G.; Peinado, R.; Rubín, J.M.; Brugada, J.; Cequier, A. “Shock Reduction With Long-Term Quinidine in Patients With Brugada Syndrome and Malignant Ventricular Arrhythmia Episodes” J Am Coll Cardiol. 2016;67(13):1653-1654.
23. Sabate M, Windecker S, Iñiguez A, Okkels-Jensen L, Cequier A, Brugaletta S, Hofma SH, Ráber L, Høi Christiansen E, Suttorp M, Pilgrim T, Anne van Es A, Sotomi Y, GarcÍa-GarcÍ HM, Onuma Y, Serruys PW. “Everolimus-eluting bioresorbable stent vs. durable polymer everolimus-eluting metallic stent in patients with ST-segment elevation myocardial infarction: results of the randomized ABSORB ST-segment elevation myocardial infarction—TROFI II trial”. European Heart Journal (2016) 37, 229–240.
24. Gomez-Lara J, Brugaletta S, Jacobi F, Ortega-Paz L, Ñato M, Roura G, Romaguera R, Ferreiro JL, Teruel L, Gracida M, Martin-Yuste V, Freixa X, Masotti M, Gomez-Hospital JA, Sabate M, Cequier A.”Five-Year Optical Coherence Tomography in Patients With ST-Segment-Elevation Myocardial Infarction Treated With Bare-Metal Versus Everolimus-Eluting Stents”. Circ Cardiovasc Interv. 2016 Oct;9(10)
25. Alegre O, Ariza-Solé A, Vidán MT, Formiga F, Martínez-Sellés M, Bueno H, Sanchís J, López-Palop R, Abu-Assi E, Cequier À. “Impact of Frailty and Other Geriatric Syndromes on Clinical Management and Outcomes in Elderly Patients With Non-ST-Segment Elevation Acute Coronary Syndromes: Rationale and Design of the LONGEVO-SCA Registry”. Clin Cardiol. 2016 Jul;39(7):373-7.